Multiple IVF Failure: Things To Understand And How To Treat

Multiple IVF Failure: Things To Understand And How To Treat

IVF is the most recognized and successful approach to dealing with infertility challenges and issues. Under this process, doctors stimulate the multiple egg growth with medication and harvest eggs – further, these eggs are fertilized in the lab with partners or donors’ sperm. This will help in the development of the embryo and doctors transfer it successfully to the uterus – It’s done now and sooner you will get a Good News.

But what happens when it results in miscarriage or failure in IVF? This is a most devastating experience for the couple which sometimes may lead to depression and anxiety.

This brings up loads of thoughts in your mind – can we conceive again? Why does this failure happen?

So, with this blog, we are coming up with some important things to consider and how to treat it.

What are the reasons for IVF Failure?

IVF is known as the most successful method for parents who want to conceive and not getting a baby due to fertility issues. However, some cases of IVF failure appear due to chromosomal abnormalities, poor embryo or egg quality, the mother’s age, abnormal sperm, uterine issues, and paternal and maternal health.

So, let‘s find every reason in detail to understand things more clearly:

Eggs Age

The quality of the embryo is influenced by the age of the egg. This can result in repeated IVF failure for women over 35. All of a woman’s eggs are present at birth, and the quality of her eggs decreases with age. The closer menopause gets,, harder it is to get viable eggs, The rate of implantation for women under 35 is approximately 45%, while the rate for women over 40 is usually 15%

Embryo Quality

The simple fact that the embryos stop developing is one of the most frequent causes of IVF failure. Embryos that do not implant after transfer frequently have a genetic flaw ,that can be identified with preimplantation testing . The embryo may  not  be healthy enough to grow, which is why it fails to implant.

Autoimmune Disorders

Roughly 10% of people suffer from autoimmune diseases, and 80% of those diagnosed with these conditions are female. When your immune system attacks healthy tissue, it can lead to inflammation and the death of those cells, which is known as an autoimmune disease. Hashimoto’s thyroiditis, Addison’s disease, celiac disease, type 1 diabetes, and lupus are a few of the more prevalent immune disorders.

Antibodies found in women with specific autoimmune diseases obstruct embryo implantation and multiple IVF failures. Some people don’t even realize they have an autoimmune disease until they start trying to figure out why they can’t get pregnant.

Chromosomal Issues

As with natural conception, the main cause of IVF failure is chromosomal abnormalities in embryos. A woman’s eggs start to exhibit more chromosomal abnormalities in her mid-30s. When she reaches her mid-40s, the percentage of these anomalies rises to an astounding 75%. As men age, the number of chromosomal abnormalities in their sperm also rises.

Before the embryos are implanted in the uterus, chromosomal abnormalities are found through preimplantation genetic screening or testing. Some couples choose not to have the testing done, and as a result, their embryo(s) may have abnormal chromosomes, which could lead to multiple IVF failures.


The same lifestyle choices that negatively impact natural conception also have an adverse effect on IVF patients. The following factors affect the success of IVF: smoking, drinking alcohol, eating poorly, or being noticeably underweight or overweight. In fact, the average number of IVF cycles required for conception is doubled and the risk of miscarriage is higher in women who smoke.

How to Treat with Multiple IVF Failure?

Even though it is very difficult to conceive after multiple failed IVF attempts, medical science has also developed treatments for this. There are multiple approaches to solving it. However, you must receive these treatments from the most qualified and experienced medical professionals.

So, here are a few things that will help you in the future after multiple IVF Failure:


If IVF does not work after several attempts, you can try again. It implies that you can attempt IVF or ICSI once more without making the same mistakes twice.

Laparoscopy /Hysteroscopy

Treating your multiple IVF failures with a laparoscopy or hysteroscopy can be very successful. In addition to helping to clear the fallopian tube blockage caused by scar tissue, this helps to explain why IVF treatments fail.

Gamete/ Uterine Rejuvenation

This is an additional, highly successful treatment for your recurrent IVF failure. It improves the quality of the egg and the quantity of platelets in the blood while determining the reason behind your IVF failure.

Embryo Glue

IVF success rates are also raised by methods such as embryo glue. The best-quality embryo is placed into the uterus with the aid of embryo glue.

Egg Freezing

Egg freezing has been shown to increase IVF success rates. The eggs are frozen at a younger age ,when the quality of eggs is good and can be used later when the patient is ready to get pregnant. The ovaries unfertilized eggs are frozen and kept until they are needed for effective IVF.

Ending Note

In vitro fertilization is appropriate for couples who require assistance in becoming pregnant. Because of the anxiety and pain associated with multiple IVF failures, it is critical for medical professionals to identify the precise cause of the failure and take appropriate action. By adhering to the treatment protocols, one can potentially make the IVF procedure successful by understanding what constitutes IVF failure and its causes. Couples may find more fulfilling happiness with IVF, so it’s appreciated that you have faith in a skilled physician and his actions.

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